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Cooperative Agreements to USA Nonprofits, For-Profits, IHEs, Agencies,
and Tribes to Prevent, Prepare for, and Mitigate the Spread of Diseases

Strengthening Healthcare Infection Prevention and Control and Improving Patient Safety in the United States

Agency Type:


Funding Source:

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Centers for Disease Control and Prevention - National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)

Conf. Date:


LOI Date:


Deadline Date:

02/11/22 11:59 PM Eastern Standard Time


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Cooperative agreements to USA and territories nonprofits, for-profits, IHEs, government agencies, and tribes to prevent, prepare for, and mitigate the spread of infectious diseases. Required registrations may take up to several weeks to finalize. Funding may be requested for projects that improve the quality and safety of healthcare or for projects that address training and education related to infection prevention and control among healthcare workers.

The COVID-19 pandemic highlighted gaps in infection prevention and control (IPC) knowledge and practice in U.S. healthcare settings. IPC in healthcare stops the spread of infections, preventing illness and death and protecting patients and healthcare personnel. There is a need to strengthen healthcare IPC practices, inform IPC recommendations, improve how healthcare personnel IPC competencies are assessed, and develop evidence-based approaches to IPC training and education. Through this NOFO, CDC will continue to protect Americans by improving the safety and quality of healthcare.

This NOFO supports the priorities of the National Center for Emerging and Zoonotic Infectious Diseases, including the prevention of the spread of infectious diseases by enhancing healthcare IPC. CDC will establish and expand partnerships with academic, healthcare, and other organizations to address common IPC failure modes; enhance correct implementation of IPC protocols and work processes; and strengthen healthcare worker training and competency assessment. Successful applicants will demonstrate specialized expertise, infrastructure, technological capabilities, and partners to strengthen healthcare IPC.
Strategies within Component 1, improving the safety and quality of healthcare and protecting healthcare personnel and patients by strengthening IPC, will:
  • Improve healthcare facility structure, design, and organization
  • Optimize materials and equipment design and safe use across healthcare settings
  • Improve IPC work processes, procedures, and practices
  • Promote standard practices to ensure healthcare environments are safe for healthcare personnel and patients
  • Strengthen healthcare IPC preparedness.
Strategies within Component two, strengthening healthcare personnel IPC training, education, and competency assessment, will:
  • Develop and evaluate innovative and effective IPC training and education approaches
  • Implement improved or novel approaches to healthcare personnel competency assessment
  • Improve the ability of the U.S. public health workforce to support healthcare IPC and prevent and respond to healthcare-associated infections (HAI) and antibiotic resistance (AR).

GrantWatch ID#:

GrantWatch ID#: 200640

Estimated Total Program Funding:


Number of Grants:

At this time, CDC estimates that 12 applicants will initially be awarded in response to this NOFO (6 for component 1 and 6 for component 2).

Estimated Size of Grant:

Approximate Total Fiscal Year Funding: $12,000,000 This amount is subject to the availability of funds.

Approximate Period of Performance Funding: $100,000,000

Approximate Average Award: $1,000,000 Per Budget Period
This is the average one-year award amount for a recipient conducting work in only one component. The average one-year award amount is subject to change and is subject to the availability of funds.

Term of Contract:

Total Period of Performance Length: 5 years
Budget Period Length: 12 month(s)


  • City or township governments
  • County governments
  • For profit organizations other than small businesses
  • Independent school districts
  • Indian housing authorities
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities
  • See RFP and/or Grant Guidelines for full eligibility
  • Small businesses
  • Special district governments
  • State governments

Additional Eligibility Criteria:

Applicants can apply to one or both components. Within each component, an applicant may include a maximum of two strategies (as defined in the logic model). Applicants must clearly state the component(s) and strategy(ies) (as defined in the logic model) to which they are applying in the Project Abstract Summary. An application will be deemed non-responsive if an applicant includes more than two strategies (as defined in the logic model) for each component included in the application.

The following types of Higher Education Institutions are always encouraged to apply for CDC support as Public or Private Non-profit Institutions of Higher Education:
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native- and Native Hawaiian-serving institutions
- Hispanic-serving institutions

Pre-proposal Conference:

Informational webinar registration information
You are invited to a Zoom webinar.
When: Jan 12, 2022
Time: 03:00-4:30 PM Eastern Time (US and Canada)
Topic: CK22-2203 Informational Webinar

Register in advance for this webinar: icon

After registering, you will receive a confirmation email containing information about joining the webinar.

Pre-Application Information:

Due Date for Applications: 02/11/2022 11:59 p.m. U.S. Eastern Standard Time

Key Dates
- Informational webinar: January 12, 2022
- Letters of intent due (recommended but not required): January 28, 2022
- Applications due: February 11, 2022

Required Registrations
An organization must be registered at the three following locations before it can submit an application for funding at
- Data Universal Number System (DUNS) (Required until April 4, 2022): This may take 1-2 business days.
- System for Award Management (SAM) formerly Central Contractor Registration (CCR): This may take 3-5 Business Days but up to 2 weeks and must be renewed once a year.
- Registration may happen on the same day but can take 8 weeks to be fully registered and approved in the system (note, applicants MUST obtain a DUNS number and SAM account before applying on

View this opportunity on

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

For programmatic technical assistance, contact:
Kate Agin Alexander
Project Officer
Department of Health and Human Services
Centers for Disease Control and Prevention
1600 Clifton Rd Atlanta GA 30303

For financial, awards management, or budget assistance, contact:
Freda Johnson
Grants Management Specialist
Department of Health and Human Services
Office of Grants Services
Telephone: 770-488-3107

For assistance with submission difficulties related to, contact the Contact Center by phone at 1-800-518-4726.
Hours of Operation: 24 hours a day, 7 days a week, except on federal holidays.

CDC Telecommunications for persons with hearing loss is available at: TTY 1-888-232-6348

CFDA Number:


Funding or Pin Number:


URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

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